PIK3CA E726K
Gene Variant Detail

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Gene PIK3CA
Variant E726K
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions PIK3CA E726K does not lie within any known functional domains of the Pik3ca protein (UniProt.org). E726K results in increased cell proliferation and migration and increased Akt phosphorylation compared to wild-type Pik3ca in culture (PMID: 34779417) and increased transformation ability in several different cell lines in culture (PMID: 29533785, PMID: 34779417).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA E726K

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Transcript NM_006218.4
gDNA chr3:g.179221146G>A
cDNA c.2176G>A
Protein p.E726K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218 chr3:g.179221146G>A c.2176G>A p.E726K RefSeq GRCh38/hg38
XM_011512894 chr3:g.179221146G>A c.2176G>A p.E726K RefSeq GRCh38/hg38
XM_006713658 chr3:g.179221146G>A c.2176G>A p.E726K RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179221146G>A c.2176G>A p.E726K RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179221146G>A c.2176G>A p.E726K RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179221146G>A c.2176G>A p.E726K RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179221146G>A c.2176G>A p.E726K RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179221146G>A c.2176G>A p.E726K RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
PIK3CA E726K gain of function Akt Inhibitor (Pan) Akt1 Inhibitor Akt2 Inhibitor mTOR Inhibitor mTORC1 Inhibitor mTORC2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor
PIK3CA E78K PIK3CA E726K PIK3CA D939G
PIK3CA E545K PIK3CA E726K
PIK3CA E726K PIK3CA H1047R
FGFR3 S249C FGFR3 E587Q FGFR3 amp PIK3CA E726K TSC1 S561fs