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PIK3CA G106R - Gene Variant Detail

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Gene PIK3CA
Variant G106R
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions PIK3CA G106R does not lie within any known functional domains of the Pik3ca protein (UniProt.org). G106R results in increased Akt phosphorylation in cell culture (PMID: 21266528), and in one of two cell lines, leads to increased cell proliferation and cell viability compared to wild-type Pik3ca in culture (PMID: 29533785), and therefore, is predicted to lead to a gain of Pik3ca protein function.
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA G106R

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Transcript NM_006218.4
gDNA chr3:g.179199141G>C
cDNA c.316G>C
Protein p.G106R
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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