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Gene PIK3CA
Variant G106V
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions PIK3CA G106V does not lie within any known functional domains of the Pik3ca proten (UniProt.org). G106V results in activation of Pik3ca as indicated by increased Akt phosphorylation in cell culture (PMID: 21266528), increased cell invasion and migration in the context of an EGFR activating mutation in vitro (PMID: 29106415), and increased transformation ability in two different cell lines (PMID: 29533785).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA act mut PIK3CA G106V

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Transcript NM_006218.4
gDNA chr3:g.179199142G>T
cDNA c.317G>T
Protein p.G106V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713658 chr3:g.179199142G>T c.317G>T p.G106V RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179199142G>T c.317G>T p.G106V RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179199142G>T c.317G>T p.G106V RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179199142G>T c.317G>T p.G106V RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179199142G>T c.317G>T p.G106V RefSeq GRCh38/hg38
XM_011512894 chr3:g.179199142G>T c.317G>T p.G106V RefSeq GRCh38/hg38
NM_006218 chr3:g.179199142G>T c.317G>T p.G106V RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179199142G>T c.317G>T p.G106V RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
PIK3CA G106V gain of function Akt Inhibitor (Pan) Akt1 Inhibitor Akt2 Inhibitor mTOR Inhibitor mTORC1 Inhibitor mTORC2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor