HRAS A146T
Gene Variant Detail

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Gene HRAS
Variant A146T
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions HRAS A146T lies within the SAK motif of the Hras protein (PMID: 24224811). A146T does not affect Hras intrinsic GTPase activity, but results in increased nucleotide exchange rates, which leads to increase GTP-bound Hras, activation of downstream signaling, and senescence of cultured cells (PMID: 24224811, PMID: 21850009).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS A146T

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Transcript NM_005343.4
gDNA chr11:g.533467C>T
cDNA c.436G>A
Protein p.A146T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_176795.4 chr11:g.533467C>T c.436G>A p.A146T RefSeq GRCh38/hg38
NM_176795 chr11:g.533467C>T c.436G>A p.A146T RefSeq GRCh38/hg38
NM_001130442 chr11:g.533467C>T c.436G>A p.A146T RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533467C>T c.436G>A p.A146T RefSeq GRCh38/hg38
NM_176795.5 chr11:g.533467C>T c.436G>A p.A146T RefSeq GRCh38/hg38
NM_005343 chr11:g.533467C>T c.436G>A p.A146T RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.533467C>T c.436G>A p.A146T RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.533467C>T c.436G>A p.A146T RefSeq GRCh38/hg38
NM_005343.3 chr11:g.533467C>T c.436G>A p.A146T RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
HRAS A146T gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)