HRAS K117R
Gene Variant Detail

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Gene HRAS
Variant K117R
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions HRAS K117R lies within the GTP binding region of the Hras protein (UniProt.org). K117R does not affect Hras intrinsic GTPase activity, but increases nucleotide exchange rates, resulting in increased GTP-boud Hras, activation of downstream signaling, and cell senescence in culture (PMID: 24224811, PMID: 17979197, PMID: 21850009).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS K117R

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Transcript NM_005343.4
gDNA chr11:g.533553T>C
cDNA c.350A>G
Protein p.K117R
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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