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Gene APC
Variant N1026S
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions APC N1026S lies within the beta-catenin binding domain of the Apc protein (PMID: 14672538). N1026S confers a loss of function on Apc, as indicated by diminished binding to Ctnnb1 and moderate activation of target genes in cell culture (PMID: 18166348).
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC N1026S

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Transcript NM_000038.6
gDNA chr5:g.112838671A>G
cDNA c.3077A>G
Protein p.N1026S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354895.1 chr5:g.112838671A>G c.3077A>G p.N1026S RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.112838671A>G c.3077A>G p.N1026S RefSeq GRCh38/hg38
NM_001127510 chr5:g.112838671A>G c.3077A>G p.N1026S RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112838671A>G c.3077A>G p.N1026S RefSeq GRCh38/hg38
NM_000038 chr5:g.112838671A>G c.3077A>G p.N1026S RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.112838671A>G c.3077A>G p.N1026S RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112838671A>G c.3077A>G p.N1026S RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112838671A>G c.3077A>G p.N1026S RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112838671A>G c.3077A>G p.N1026S RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References