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Gene FLT3
Variant I867S
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FLT3 I867S lies within the protein kinase domain of the Flt3 protein (UniProt.org). I867S results in constitutive phosphorylation of Flt3 and activation of Akt signaling, leading to transformation of cultured cells (PMID: 24608088)
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 I867S

FLT3 mutant FLT3 exon21 FLT3 I867S

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Transcript NM_004119.3
gDNA chr13:g.28015643A>C
cDNA c.2600T>G
Protein p.I867S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28015643A>C c.2600T>G p.I867S RefSeq GRCh38/hg38
NM_004119 chr13:g.28015643A>C c.2600T>G p.I867S RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28015643A>C c.2600T>G p.I867S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
FLT3 I867S gain of function FLT3 Inhibitor