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FLT3 M737I - Gene Variant Detail

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Gene FLT3
Variant M737I
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions FLT3 M737I lies within the protein kinase domain of the Flt3 protein (UniProt.org). M737I does not result in Il-3 independent growth of cultured cells (PMID: 18068628), and therefore, is predicted to have no effect on Flt3 protein function.
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 exon18 FLT3 M737I

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Transcript NM_004119.3
gDNA chr13:g.28024940C>G
cDNA c.2211G>C
Protein p.M737I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28024940C>G c.2211G>C p.M737I RefSeq GRCh38/hg38
NM_004119 chr13:g.28024940C>G c.2211G>C p.M737I RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28024940C>G c.2211G>C p.M737I RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References