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Gene | FLT3 |
Variant | M737I |
Impact List | missense |
Protein Effect | no effect - predicted |
Gene Variant Descriptions | FLT3 M737I lies within the protein kinase domain of the Flt3 protein (UniProt.org). M737I does not result in Il-3 independent growth of cultured cells (PMID: 18068628), and therefore, is predicted to have no effect on Flt3 protein function. |
Associated Drug Resistance | |
Category Variants Paths |
FLT3 mutant FLT3 exon18 FLT3 M737I |
Transcript | NM_004119.3 |
gDNA | chr13:g.28024940C>G |
cDNA | c.2211G>C |
Protein | p.M737I |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_004119.2 | chr13:g.28024940C>G | c.2211G>C | p.M737I | RefSeq | GRCh38/hg38 |
NM_004119.3 | chr13:g.28024940C>G | c.2211G>C | p.M737I | RefSeq | GRCh38/hg38 |
NM_004119 | chr13:g.28024940C>G | c.2211G>C | p.M737I | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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