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Gene FLT3
Variant S451E
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FLT3 S451E lies within the extracellular domain of the Flt3 protein (UniProt.org). S451E has not been characterized in the scientific literature and therefore, its effect on Flt3 protein function is unknown (PubMed, Dec 2023).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 S451E

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Transcript NM_004119.3
gDNA chr13:g.28036000_28036002delTCCinsGAG
cDNA c.1351_1353delTCCinsGAG
Protein p.S451E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119 chr13:g.28036000_28036002delGGAinsCTC c.1351_1353delTCCinsGAG p.S451E RefSeq GRCh38/hg38
XM_017020486 chr13:g.28035523_28035525delAGAinsCTC c.1351_1353delTCTinsGAG p.S451E RefSeq GRCh38/hg38
NM_004119.2 chr13:g.28036000_28036002delTCCinsGAG c.1351_1353delTCCinsGAG p.S451E RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28036000_28036002delTCCinsGAG c.1351_1353delTCCinsGAG p.S451E RefSeq GRCh38/hg38
XM_017020486.1 chr13:g.28035523_28035525delTCTinsGAG c.1351_1353delTCTinsGAG p.S451E RefSeq GRCh38/hg38
XM_017020486.2 chr13:g.28035523_28035525delTCTinsGAG c.1351_1353delTCTinsGAG p.S451E RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References