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Gene FLT3
Variant V579A
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FLT3 V579A lies within the cytoplasmic domain of the Flt3 protein (UniProt.org). V579A results in constitutive phosphorylation of Flt3, activation of Stat5 signaling, and is transforming in culture (PMID: 16410449).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 V579A

FLT3 mutant FLT3 exon14 FLT3 V579A

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Transcript NM_004119.3
gDNA chr13:g.28034183A>G
cDNA c.1736T>C
Protein p.V579A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28034183A>G c.1736T>C p.V579A RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28034183A>G c.1736T>C p.V579A RefSeq GRCh38/hg38
NM_004119 chr13:g.28034183A>G c.1736T>C p.V579A RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References