FLT3 I836_M837insIRC
Gene Variant Detail

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Gene FLT3
Variant I836_M837insIRC
Impact List insertion
Protein Effect unknown
Gene Variant Descriptions FLT3 I836_M837insIRC results in the insertion of three amino acids in the protein kinase domain of the Flt3 protein between amino acids 836 and 837 (UniProt.org). I836_M837insIRC has not been characterized in the scientific literature and therefore, its effect on Flt3 protein function is unknown (PubMed, Dec 2025).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 exon20 FLT3 I836_M837insIRC

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Transcript NM_004119.3
gDNA chr13:g.28018499_28018500insACACCTGAT
cDNA c.2510_2511insCAGGTGTAT
Protein p.I836_M837insIRC
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28018499_28018500insACACCTGAT c.2510_2511insCAGGTGTAT p.I836_M837insIRC RefSeq GRCh38/hg38
NM_004119 chr13:g.28018499_28018500insACACCTGAT c.2510_2511insCAGGTGTAT p.I836_M837insIRC RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28018499_28018500insACACCTGAT c.2510_2511insCAGGTGTAT p.I836_M837insIRC RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References