CDK12 K756R
Gene Variant Detail

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Gene CDK12
Variant K756R
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions CDK12 K756R lies within the protein kinase domain of the Cdk12 protein (UniProt.org). K756R results in decreased Cdk12 kinase activity in an in vitro assay and results in decreased homologous repair as demonstrated by failure to restore Rad51 foci formation in Cdk12-depleted cells in culture (PMID: 24554720).
Associated Drug Resistance
Category Variants Paths

CDK12 mutant CDK12 inact mut CDK12 K756R

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Transcript NM_016507.4
gDNA chr17:g.39494542A>G
cDNA c.2267A>G
Protein p.K756R
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.