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Gene CDKN2A
Variant G35A
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions CDKN2A G35A lies within ANK repeat 1 of the Cdkn2a protein (UniProt.org). G35A confers a loss of function to the Cdkn2a protein, as demonstrated by a partial loss of Cdk4 binding and aberrant proliferation of cells in culture (PMID: 19260062).
Associated Drug Resistance
Category Variants Paths

CDKN2A mutant CDKN2A inact mut CDKN2A G35A

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Transcript NM_000077.5
gDNA chr9:g.21974724C>G
cDNA c.104G>C
Protein p.G35A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_058197 chr9:g.21974724C>G c.104G>C p.G35A RefSeq GRCh38/hg38
NM_001195132.2 chr9:g.21974724C>G c.104G>C p.G35A RefSeq GRCh38/hg38
XM_011517675 chr9:g.21974724C>G c.104G>C p.G35A RefSeq GRCh38/hg38
NM_000077.5 chr9:g.21974724C>G c.104G>C p.G35A RefSeq GRCh38/hg38
NM_058197.4 chr9:g.21974724C>G c.104G>C p.G35A RefSeq GRCh38/hg38
NM_001195132.1 chr9:g.21974724C>G c.104G>C p.G35A RefSeq GRCh38/hg38
XM_011517676.2 chr9:g.21974724C>G c.104G>C p.G35A RefSeq GRCh38/hg38
XM_011517676 chr9:g.21974724C>G c.104G>C p.G35A RefSeq GRCh38/hg38
XM_011517675.2 chr9:g.21974724C>G c.104G>C p.G35A RefSeq GRCh38/hg38
XM_011517675.3 chr9:g.21974724C>G c.104G>C p.G35A RefSeq GRCh38/hg38
NM_000077 chr9:g.21974724C>G c.104G>C p.G35A RefSeq GRCh38/hg38
NM_001195132 chr9:g.21974724C>G c.104G>C p.G35A RefSeq GRCh38/hg38
NM_058197.5 chr9:g.21974724C>G c.104G>C p.G35A RefSeq GRCh38/hg38
XM_011517676.3 chr9:g.21974724C>G c.104G>C p.G35A RefSeq GRCh38/hg38
NM_000077.4 chr9:g.21974724C>G c.104G>C p.G35A RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
CDKN2A G35A loss of function