STK11 K78A
Gene Variant Detail

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Gene STK11
Variant K78A
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions STK11 K78A lies within the protein kinase domain of the Stk11 protein (UniProt.org). K78A results in loss of kinase activity (PMID: 15800014), loss of Ampk activation, loss of apicobasal cell polarization and increased colony formation and anchorage-independent growth in culture (PMID: 24998845).
Associated Drug Resistance
Category Variants Paths

STK11 mutant STK11 inact mut STK11 K78A

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Transcript NM_000455.5
gDNA chr19:g.1207145_1207146delAAinsGC
cDNA c.232_233delAAinsGC
Protein p.K78A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005259618.3 chr19:g.1207145_1207146delAAinsGC c.232_233delAAinsGC p.K78A RefSeq GRCh38/hg38
XM_005259617 chr19:g.1207145_1207146delAAinsGC c.232_233delAAinsGC p.K78A RefSeq GRCh38/hg38
XM_005259618 chr19:g.1207145_1207146delAAinsGC c.232_233delAAinsGC p.K78A RefSeq GRCh38/hg38
NM_000455.4 chr19:g.1207145_1207146delAAinsGC c.232_233delAAinsGC p.K78A RefSeq GRCh38/hg38
XM_005259617.3 chr19:g.1207145_1207146delAAinsGC c.232_233delAAinsGC p.K78A RefSeq GRCh38/hg38
NM_000455.5 chr19:g.1207145_1207146delAAinsGC c.232_233delAAinsGC p.K78A RefSeq GRCh38/hg38
NM_000455 chr19:g.1207145_1207146delAAinsGC c.232_233delAAinsGC p.K78A RefSeq GRCh38/hg38
NM_001407255.1 chr19:g.1207145_1207146delAAinsGC c.232_233delAAinsGC p.K78A RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References