STK11 R304W - Gene Variant Detail

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Gene STK11
Variant R304W
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions STK11 R304W lies within the protein kinase domain of the Stk11 protein (UniProt.org). R304W confers a loss of function to the Stk11 protein as demonstrated by loss of autophosphorylation, lack of cytoplasmic localization, and the inability to suppress growth in culture (PMID: 12552571).
Associated Drug Resistance
Category Variants Paths

STK11 mutant STK11 inact mut STK11 R304W

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Transcript NM_000455.5
gDNA chr19:g.1221996C>T
cDNA c.910C>T
Protein p.R304W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005259617 chr19:g.1221996C>T c.910C>T p.R304W RefSeq GRCh38/hg38
XM_005259618.3 chr19:g.1221996C>T c.910C>T p.R304W RefSeq GRCh38/hg38
NM_000455.5 chr19:g.1221996C>T c.910C>T p.R304W RefSeq GRCh38/hg38
XM_005259618 chr19:g.1221996C>T c.910C>T p.R304W RefSeq GRCh38/hg38
NM_000455 chr19:g.1221996C>T c.910C>T p.R304W RefSeq GRCh38/hg38
NM_000455.4 chr19:g.1221996C>T c.910C>T p.R304W RefSeq GRCh38/hg38
XM_005259617.3 chr19:g.1221996C>T c.910C>T p.R304W RefSeq GRCh38/hg38
NM_001407255.1 chr19:g.1221996C>T c.910C>T p.R304W RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries