Gene Variant Detail

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Gene PIK3CA
Variant A1046_H1047insTSA
Impact List insertion
Protein Effect unknown
Gene Variant Descriptions PIK3CA A1046_H1047insTSA results in the insertion of three amino acids in the PI3K/PI4K domain of the Pik3ca protein between amino acids 1046 and 1047 (UniProt.org). A1046_H1047insTSA has not been characterized in the scientific literature and therefore, its effect on Pik3ca protein function is unknown (PubMed, Mar 2024).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon21 PIK3CA A1046_H1047insTSA

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Transcript NM_006218.4
gDNA chr3:g.179234295_179234296insACAAGCGCA
cDNA c.3138_3139insACAAGCGCA
Protein p.A1046_H1047insTSA
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011512894 chr3:g.179234295_179234296insACAAGCGCA c.3138_3139insACAAGCGCA p.A1046_H1047insTSA RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179234295_179234296insACAAGCGCA c.3138_3139insACAAGCGCA p.A1046_H1047insTSA RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179234295_179234296insACAAGCGCA c.3138_3139insACAAGCGCA p.A1046_H1047insTSA RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179234295_179234296insACAAGCGCA c.3138_3139insACAAGCGCA p.A1046_H1047insTSA RefSeq GRCh38/hg38
NM_006218 chr3:g.179234295_179234296insACAAGCGCA c.3138_3139insACAAGCGCA p.A1046_H1047insTSA RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179234295_179234296insACAAGCGCA c.3138_3139insACAAGCGCA p.A1046_H1047insTSA RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179234295_179234296insACAAGCGCA c.3138_3139insACAAGCGCA p.A1046_H1047insTSA RefSeq GRCh38/hg38
XM_006713658 chr3:g.179234295_179234296insACAAGCGCA c.3138_3139insACAAGCGCA p.A1046_H1047insTSA RefSeq GRCh38/hg38

Filtering

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References