POLE V411L
Gene Variant Detail

Request Content

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene POLE
Variant V411L
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions POLE V411L lies within the exonuclease domain of the Pole protein (PMID: 29352080). V411L results in reduced Pole exonuclease activity in an in vitro assay (PMID: 25228659), and therefore, is predicted to lead to a loss of Pole protein function.
Associated Drug Resistance
Category Variants Paths

POLE mutant POLE inact mut POLE V411L

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_006231.4
gDNA chr12:g.132673703C>G
cDNA c.1231G>C
Protein p.V411L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006231 chr12:g.132673703C>G c.1231G>C p.V411L RefSeq GRCh38/hg38
XM_011534795.3 chr12:g.132673703C>G c.1231G>C p.V411L RefSeq GRCh38/hg38
XM_011534795 chr12:g.132673703C>G c.1231G>C p.V411L RefSeq GRCh38/hg38
XM_011534800 chr12:g.132673703C>G c.1231G>C p.V411L RefSeq GRCh38/hg38
XM_011534799 chr12:g.132673703C>G c.1231G>C p.V411L RefSeq GRCh38/hg38
NM_006231.3 chr12:g.132673703C>G c.1231G>C p.V411L RefSeq GRCh38/hg38
NM_006231.4 chr12:g.132673703C>G c.1231G>C p.V411L RefSeq GRCh38/hg38
XM_011534795.4 chr12:g.132673703C>G c.1231G>C p.V411L RefSeq GRCh38/hg38
XM_011534799.3 chr12:g.132673703C>G c.1231G>C p.V411L RefSeq GRCh38/hg38
XM_047429018.1 chr12:g.132673703C>G c.1231G>C p.V411L RefSeq GRCh38/hg38
XM_011534799.2 chr12:g.132673703C>G c.1231G>C p.V411L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
POLE V411L loss of function - predicted
CD274 pos POLE R114* POLE V411L