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Gene APC
Variant K1817fs
Impact List frameshift
Protein Effect unknown
Gene Variant Descriptions APC K1817fs results in a change in the amino acid sequence of the Apc protein beginning at aa 1817 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). K1817fs has not been characterized in the scientific literature and therefore, its effect on Apc protein function is unknown (PubMed, Aug 2024).
Associated Drug Resistance
Category Variants Paths

APC mutant APC K1817fs

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Transcript NM_000038.6
gDNA chr5:g.(112841042_112841043)
cDNA c.(5449_5448)
Protein p.K1817fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354895.1 chr5:g.(112841042_112841043) c.(5449_5448) p.K1817fs RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.(112841042_112841043) c.(5449_5448) p.K1817fs RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.(112841042_112841043) c.(5449_5448) p.K1817fs RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.(112841042_112841043) c.(5449_5448) p.K1817fs RefSeq GRCh38/hg38
NM_000038.5 chr5:g.(112841042_112841043) c.(5449_5448) p.K1817fs RefSeq GRCh38/hg38
NM_001127510 chr5:g.(112841042_112841043) c.(5449_5448) p.K1817fs RefSeq GRCh38/hg38
NM_000038 chr5:g.(112841042_112841043) c.(5449_5448) p.K1817fs RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.(112841042_112841043) c.(5449_5448) p.K1817fs RefSeq GRCh38/hg38
NM_000038.6 chr5:g.(112841042_112841043) c.(5449_5448) p.K1817fs RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References