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Gene APC
Variant N741fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions APC N741fs results in a change in the amino acid sequence of the Apc protein beginning at aa 741 of 2843, likely resulting in premature truncation of the functional protein (UniProt.org). N741fs has not been characterized, however, due to the effects of other truncation mutations downstream of N741 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC N741fs

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Transcript NM_000038.6
gDNA chr5:g.(112837814_112837815)
cDNA c.(2221_2220)
Protein p.N741fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000038 chr5:g.(112837814_112837815) c.(2221_2220) p.N741fs RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.(112837814_112837815) c.(2221_2220) p.N741fs RefSeq GRCh38/hg38
NM_000038.6 chr5:g.(112837814_112837815) c.(2221_2220) p.N741fs RefSeq GRCh38/hg38
NM_001127510 chr5:g.(112837814_112837815) c.(2221_2220) p.N741fs RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.(112837814_112837815) c.(2221_2220) p.N741fs RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.(112837814_112837815) c.(2221_2220) p.N741fs RefSeq GRCh38/hg38
NM_000038.5 chr5:g.(112837814_112837815) c.(2221_2220) p.N741fs RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.(112837814_112837815) c.(2221_2220) p.N741fs RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.(112837814_112837815) c.(2221_2220) p.N741fs RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries