Gene Variant Detail

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Gene ATR
Variant F676fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions ATR F676fs results in a change in the amino acid sequence of the Atr protein beginning at aa 676 of 2644, likely resulting in premature truncation of the functional protein (UniProt.org). Due to the loss of the PI3K/PI4K domain and the FATC domain (UniProt.org), F676fs is predicted to lead to a loss of Atr protein function.
Associated Drug Resistance
Category Variants Paths

ATR mutant ATR inact mut ATR F676fs

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Transcript NM_001184.4
gDNA chr3:g.(142556435_142556436)
cDNA c.(2026_2025)
Protein p.F676fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011512926 chr3:g.(142556435_142556436) c.(2026_2025) p.F676fs RefSeq GRCh38/hg38
XM_047448364.1 chr3:g.(142556435_142556436) c.(2026_2025) p.F676fs RefSeq GRCh38/hg38
XM_047448362.1 chr3:g.(142556435_142556436) c.(2026_2025) p.F676fs RefSeq GRCh38/hg38
XM_011512924.1 chr3:g.(142556435_142556436) c.(2026_2025) p.F676fs RefSeq GRCh38/hg38
NM_001184 chr3:g.(142556435_142556436) c.(2026_2025) p.F676fs RefSeq GRCh38/hg38
XM_047448361.1 chr3:g.(142556435_142556436) c.(2026_2025) p.F676fs RefSeq GRCh38/hg38
XM_047448360.1 chr3:g.(142556435_142556436) c.(2026_2025) p.F676fs RefSeq GRCh38/hg38
XM_047448363.1 chr3:g.(142556435_142556436) c.(2026_2025) p.F676fs RefSeq GRCh38/hg38
XM_011512924 chr3:g.(142556435_142556436) c.(2026_2025) p.F676fs RefSeq GRCh38/hg38
NM_001184.3 chr3:g.(142556435_142556436) c.(2026_2025) p.F676fs RefSeq GRCh38/hg38
NM_001184.4 chr3:g.(142556435_142556436) c.(2026_2025) p.F676fs RefSeq GRCh38/hg38
XM_011512924.2 chr3:g.(142556435_142556436) c.(2026_2025) p.F676fs RefSeq GRCh38/hg38

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries