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Gene NRAS
Variant Y64D
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS Y64D does not lie within any known functional domains of the Nras protein (UniProt.org). Y64D does not promote tumor formation in animal models in a pooled screening assay and induces a gene expression profile less correlated with activating NRAS variants in culture (PMID: 27147599), and based on the effects of HRAS Y64D, which results in a loss of Hras GTPase activity in in vitro assays and failure to transform cells in culture (PMID: 1730690), is predicted to lead to a loss of Nras protein function.
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS exon3 NRAS Y64D

NRAS mutant NRAS inact mut NRAS Y64D

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Transcript NM_002524.5
gDNA chr1:g.114713900A>C
cDNA c.190T>G
Protein p.Y64D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524 chr1:g.114713900A>C c.190T>G p.Y64D RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114713900A>C c.190T>G p.Y64D RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114713900A>C c.190T>G p.Y64D RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
NRAS Y64D loss of function - predicted