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Gene | TP53 |
Variant | A276_G279del |
Impact List | deletion |
Protein Effect | unknown |
Gene Variant Descriptions | TP53 A276_G279del results in the deletion of four amino acids in the DNA-binding domain of the Tp53 protein from amino acids 276 to 279 (PMID: 21760703). A276_G279del has not been characterized in the scientific literature and therefore, its effect on Tp53 protein function is unknown (PubMed, Jul 2024). |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon8 TP53 A276_G279del |
Transcript | NM_000546.6 |
gDNA | chr17:g.7673783_7673794del12 |
cDNA | c.826_837del12 |
Protein | p.A276_G279delACPG |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_001407266.1 | chr17:g.7673783_7673794del12 | c.826_837del12 | p.A276_G279delACPG | RefSeq | GRCh38/hg38 |
NM_000546.5 | chr17:g.7673783_7673794del12 | c.826_837del12 | p.A276_G279del | RefSeq | GRCh38/hg38 |
NM_001407262.1 | chr17:g.7673783_7673794del12 | c.826_837del12 | p.A276_G279delACPG | RefSeq | GRCh38/hg38 |
NM_001407267.1 | chr17:g.7673574_7673585del12 | c.826_837del12 | p.S276_P279delSPQP | RefSeq | GRCh38/hg38 |
NM_001407269.1 | chr17:g.7673574_7673585del12 | c.826_837del12 | p.S276_P279delSPQP | RefSeq | GRCh38/hg38 |
NM_000546.6 | chr17:g.7673783_7673794del12 | c.826_837del12 | p.A276_G279delACPG | RefSeq | GRCh38/hg38 |
NM_001407265.1 | chr17:g.7673574_7673585del12 | c.826_837del12 | p.S276_P279delSPQP | RefSeq | GRCh38/hg38 |
NM_001407263.1 | chr17:g.7673574_7673585del12 | c.826_837del12 | p.S276_P279delSPQP | RefSeq | GRCh38/hg38 |
NM_001407270.1 | chr17:g.7673783_7673794del12 | c.826_837del12 | p.A276_G279delACPG | RefSeq | GRCh38/hg38 |
NM_001407271.1 | chr17:g.7673574_7673585del12 | c.826_837del12 | p.S276_P279delSPQP | RefSeq | GRCh38/hg38 |
NM_001126113.3 | chr17:g.7673783_7673794del12 | c.826_837del12 | p.A276_G279delACPG | RefSeq | GRCh38/hg38 |
NM_001126118.2 | chr17:g.7673574_7673585del12 | c.826_837del12 | p.S276_P279delSPQP | RefSeq | GRCh38/hg38 |
NM_001407268.1 | chr17:g.7673783_7673794del12 | c.826_837del12 | p.A276_G279delACPG | RefSeq | GRCh38/hg38 |
NM_001407264.1 | chr17:g.7673783_7673794del12 | c.826_837del12 | p.A276_G279delACPG | RefSeq | GRCh38/hg38 |
NM_001276761.3 | chr17:g.7673574_7673585del12 | c.826_837del12 | p.S276_P279delSPQP | RefSeq | GRCh38/hg38 |
NM_001126112.3 | chr17:g.7673783_7673794del12 | c.826_837del12 | p.A276_G279delACPG | RefSeq | GRCh38/hg38 |
NM_001276695.3 | chr17:g.7673574_7673585del12 | c.826_837del12 | p.S276_P279delSPQP | RefSeq | GRCh38/hg38 |
NM_001276696.3 | chr17:g.7673574_7673585del12 | c.826_837del12 | p.S276_P279delSPQP | RefSeq | GRCh38/hg38 |
NM_001276760.3 | chr17:g.7673574_7673585del12 | c.826_837del12 | p.S276_P279delSPQP | RefSeq | GRCh38/hg38 |
NM_001126114.3 | chr17:g.7673783_7673794del12 | c.826_837del12 | p.A276_G279delACPG | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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