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Gene TP53
Variant A276_G279del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions TP53 A276_G279del results in the deletion of four amino acids in the DNA-binding domain of the Tp53 protein from amino acids 276 to 279 (PMID: 21760703). A276_G279del has not been characterized in the scientific literature and therefore, its effect on Tp53 protein function is unknown (PubMed, Jul 2024).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon8 TP53 A276_G279del

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Transcript NM_000546.6
gDNA chr17:g.7673783_7673794del12
cDNA c.826_837del12
Protein p.A276_G279delACPG
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001276696.3 chr17:g.7673574_7673585del12 c.826_837del12 p.S276_P279delSPQP RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7673783_7673794del12 c.826_837del12 p.A276_G279delACPG RefSeq GRCh38/hg38
NM_001276695.3 chr17:g.7673574_7673585del12 c.826_837del12 p.S276_P279delSPQP RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7673783_7673794del12 c.826_837del12 p.A276_G279delACPG RefSeq GRCh38/hg38
NM_001407269.1 chr17:g.7673574_7673585del12 c.826_837del12 p.S276_P279delSPQP RefSeq GRCh38/hg38
NM_001407271.1 chr17:g.7673574_7673585del12 c.826_837del12 p.S276_P279delSPQP RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7673783_7673794del12 c.826_837del12 p.A276_G279delACPG RefSeq GRCh38/hg38
NM_001276761.3 chr17:g.7673574_7673585del12 c.826_837del12 p.S276_P279delSPQP RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7673783_7673794del12 c.826_837del12 p.A276_G279delACPG RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7673783_7673794del12 c.826_837del12 p.A276_G279delACPG RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7673783_7673794del12 c.826_837del12 p.A276_G279del RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7673783_7673794del12 c.826_837del12 p.A276_G279delACPG RefSeq GRCh38/hg38
NM_001407265.1 chr17:g.7673574_7673585del12 c.826_837del12 p.S276_P279delSPQP RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7673783_7673794del12 c.826_837del12 p.A276_G279delACPG RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7673783_7673794del12 c.826_837del12 p.A276_G279delACPG RefSeq GRCh38/hg38
NM_001407267.1 chr17:g.7673574_7673585del12 c.826_837del12 p.S276_P279delSPQP RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7673783_7673794del12 c.826_837del12 p.A276_G279delACPG RefSeq GRCh38/hg38
NM_001126118.2 chr17:g.7673574_7673585del12 c.826_837del12 p.S276_P279delSPQP RefSeq GRCh38/hg38
NM_001276760.3 chr17:g.7673574_7673585del12 c.826_837del12 p.S276_P279delSPQP RefSeq GRCh38/hg38
NM_001407263.1 chr17:g.7673574_7673585del12 c.826_837del12 p.S276_P279delSPQP RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
TP53 A276_G279del unknown