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Gene TET2
Variant Y1902A
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions TET2 Y1902A lies within the substrate-binding region of the Tet2 protein (UniProt.org). Y1902A results in loss of catalytic activity in an in vitro assay (PMID: 30028600), and therefore, is predicted to lead to a loss of Tet2 protein function.
Associated Drug Resistance
Category Variants Paths

TET2 mutant TET2 inact mut TET2 Y1902A

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Transcript NM_001127208.3
gDNA chr4:g.105276214_105276215delTAinsGC
cDNA c.5704_5705delTAinsGC
Protein p.Y1902A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001127208 chr4:g.105276214_105276215delTAinsGC c.5704_5705delTAinsGC p.Y1902A RefSeq GRCh38/hg38
XM_024454103.1 chr4:g.105276214_105276215delTAinsGC c.5704_5705delTAinsGC p.Y1902A RefSeq GRCh38/hg38
XM_005263082.3 chr4:g.105276214_105276215delTAinsGC c.5704_5705delTAinsGC p.Y1902A RefSeq GRCh38/hg38
XM_005263082 chr4:g.105276214_105276215delTAinsGC c.5704_5705delTAinsGC p.Y1902A RefSeq GRCh38/hg38
NM_001127208.2 chr4:g.105276214_105276215delTAinsGC c.5704_5705delTAinsGC p.Y1902A RefSeq GRCh38/hg38
NM_001127208.3 chr4:g.105276214_105276215delTAinsGC c.5704_5705delTAinsGC p.Y1902A RefSeq GRCh38/hg38
XM_024454102.1 chr4:g.105276214_105276215delTAinsGC c.5704_5705delTAinsGC p.Y1902A RefSeq GRCh38/hg38
XM_005263082.4 chr4:g.105276214_105276215delTAinsGC c.5704_5705delTAinsGC p.Y1902A RefSeq GRCh38/hg38
XM_024454103.2 chr4:g.105276214_105276215delTAinsGC c.5704_5705delTAinsGC p.Y1902A RefSeq GRCh38/hg38
XM_024454102.2 chr4:g.105276214_105276215delTAinsGC c.5704_5705delTAinsGC p.Y1902A RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
TET2 Y1902A loss of function - predicted