Gene Variant Detail

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Gene FGFR2
Variant G183fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions FGFR2 G183fs results in a change in the amino acid sequence of the Fgfr2 protein beginning at aa 183 of 821, likely resulting in premature truncation of the functional protein (UniProt.org). Due to the loss of the protein kinase domain (UniProt.org), G183fs is predicted to lead to a loss of Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 exon5 FGFR2 G183fs

FGFR2 mutant FGFR2 inact mut FGFR2 G183fs

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Transcript NM_000141.5
gDNA chr10:g.(121551367_121551368)
cDNA c.(547_546)
Protein p.G183fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_023029.2 chr10:g.(121520104_121520105) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_001144915 chr10:g.(121520104_121520105) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_001144916.2 chr10:g.(121520026_121520027) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_001144915.1 chr10:g.(121520104_121520105) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_001144916.1 chr10:g.(121520026_121520027) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.(121551367_121551368) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_001144919.1 chr10:g.(121520104_121520105) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_001144918 chr10:g.(121520026_121520027) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_000141.5 chr10:g.(121551367_121551368) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_001144914.1 chr10:g.(121551367_121551368) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.(121551367_121551368) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_001320658 chr10:g.(121551367_121551368) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_000141.4 chr10:g.(121551367_121551368) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_001144917.1 chr10:g.(121551367_121551368) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_001144919 chr10:g.(121520104_121520105) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_001144914.1 chr10:g.(121551367_121551368) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_001144914 chr10:g.(121551367_121551368) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_022970 chr10:g.(121551367_121551368) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_001144917 chr10:g.(121551367_121551368) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_022970.4 chr10:g.(121551367_121551368) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_023029 chr10:g.(121520104_121520105) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_023029.2 chr10:g.(121520104_121520105) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_001144918.1 chr10:g.(121520026_121520027) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_001144915.2 chr10:g.(121520104_121520105) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.(121551367_121551368) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_001144918.2 chr10:g.(121520026_121520027) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_001144916 chr10:g.(121520026_121520027) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_001144913 chr10:g.(121551367_121551368) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_001144919.2 chr10:g.(121520104_121520105) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.(121551367_121551368) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.(121551367_121551368) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_000141 chr10:g.(121551367_121551368) c.(547_546) p.G183fs RefSeq GRCh38/hg38
NM_022970.3 chr10:g.(121551367_121551368) c.(547_546) p.G183fs RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References