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Gene APC
Variant G1312R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions APC G1312R lies within a region of the Apc protein responsible for downregulation mediated by ubiquitination (UniProt.org). G1312R has been identified in sequencing studies (PMID: 27147599), but has not been biochemically characterized and therefore, its effect on Apc protein function is unknown (PubMed, Jun 2024).
Associated Drug Resistance
Category Variants Paths

APC mutant APC G1312R

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Transcript NM_000038.6
gDNA chr5:g.112839528G>A
cDNA c.3934G>A
Protein p.G1312R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001127510.3 chr5:g.112839528G>A c.3934G>A p.G1312R RefSeq GRCh38/hg38
NM_001127510 chr5:g.112839528G>A c.3934G>A p.G1312R RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.112839528G>A c.3934G>A p.G1312R RefSeq GRCh38/hg38
NM_000038 chr5:g.112839528G>A c.3934G>A p.G1312R RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.112839528G>A c.3934G>A p.G1312R RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112839528G>A c.3934G>A p.G1312R RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112839528G>A c.3934G>A p.G1312R RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.112839528G>A c.3934G>A p.G1312R RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112839528G>A c.3934G>A p.G1312R RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References