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FGFR1 K656D - Gene Variant Detail

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Gene FGFR1
Variant K656D
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR1 K656D lies within the protein kinase domain of the Fgfr1 protein (UniProt.org). K656D has been identified in the scientific literature (PMID: 26920151, PMID: 24750136, PMID: 23817572), but has not been biochemically characterized and therefore, its effect on Fgfr1 protein function is unknown (PubMed, Apr 2025).
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 K656D

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Transcript NM_023110.3
gDNA chr8:g.38414788_38414790delAAGinsGAC
cDNA c.1966_1968delAAGinsGAC
Protein p.K656D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011544449 chr8:g.38414196_38414198delCTTinsGTC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_011544449.1 chr8:g.38414196_38414198delAAGinsGAC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_011544449.2 chr8:g.38414196_38414198delAAGinsGAC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
NM_023110 chr8:g.38414788_38414790delCTTinsGTC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_011544450 chr8:g.38414196_38414198delCTTinsGTC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_017013226.2 chr8:g.38414196_38414198delAAGinsGAC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_017013226.1 chr8:g.38414196_38414198delAAGinsGAC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_006716304.2 chr8:g.38414788_38414790delAAGinsGAC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_006716303 chr8:g.38414788_38414790delCTTinsGTC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_011544450.2 chr8:g.38414196_38414198delAAGinsGAC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_017013221.1 chr8:g.38414788_38414790delAAGinsGAC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_017013221.2 chr8:g.38414788_38414790delAAGinsGAC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_006716304.1 chr8:g.38414788_38414790delAAGinsGAC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
NM_023110.2 chr8:g.38414788_38414790delAAGinsGAC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
NM_023110.3 chr8:g.38414788_38414790delAAGinsGAC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_006716303.3 chr8:g.38414788_38414790delAAGinsGAC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_047421575.1 chr8:g.38415855_38415857delAAGinsGAC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_006716303.4 chr8:g.38414788_38414790delAAGinsGAC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_017013221 chr8:g.38414788_38414790delCTTinsGTC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_011544450.3 chr8:g.38414196_38414198delAAGinsGAC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_017013226 chr8:g.38414196_38414198delCTTinsGTC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_006716304 chr8:g.38414788_38414790delCTTinsGTC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References