FGFR1 K656D
Gene Variant Detail

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Gene FGFR1
Variant K656D
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR1 K656D lies within the protein kinase domain of the Fgfr1 protein (UniProt.org). K656D has been identified in the scientific literature (PMID: 26920151, PMID: 24750136, PMID: 23817572), but has not been biochemically characterized and therefore, its effect on Fgfr1 protein function is unknown (PubMed, Oct 2025).
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 K656D

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Transcript NM_023110.3
gDNA chr8:g.38414788_38414790delAAGinsGAC
cDNA c.1966_1968delAAGinsGAC
Protein p.K656D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_023110.2 chr8:g.38414788_38414790delAAGinsGAC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_011544449 chr8:g.38414196_38414198delCTTinsGTC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_017013226.1 chr8:g.38414196_38414198delAAGinsGAC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_017013226.2 chr8:g.38414196_38414198delAAGinsGAC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_006716304.2 chr8:g.38414788_38414790delAAGinsGAC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_017013226 chr8:g.38414196_38414198delCTTinsGTC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_017013221.2 chr8:g.38414788_38414790delAAGinsGAC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_017013221.1 chr8:g.38414788_38414790delAAGinsGAC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_011544450.2 chr8:g.38414196_38414198delAAGinsGAC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_006716303.3 chr8:g.38414788_38414790delAAGinsGAC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_047421575.1 chr8:g.38415855_38415857delAAGinsGAC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_017013221 chr8:g.38414788_38414790delCTTinsGTC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_006716304 chr8:g.38414788_38414790delCTTinsGTC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_011544449.1 chr8:g.38414196_38414198delAAGinsGAC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_006716304.1 chr8:g.38414788_38414790delAAGinsGAC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_011544450.3 chr8:g.38414196_38414198delAAGinsGAC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_006716303 chr8:g.38414788_38414790delCTTinsGTC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
NM_023110 chr8:g.38414788_38414790delCTTinsGTC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_011544450 chr8:g.38414196_38414198delCTTinsGTC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_006716303.4 chr8:g.38414788_38414790delAAGinsGAC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
XM_011544449.2 chr8:g.38414196_38414198delAAGinsGAC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38
NM_023110.3 chr8:g.38414788_38414790delAAGinsGAC c.1966_1968delAAGinsGAC p.K656D RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References