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Gene | FGFR1 |
Variant | K656N |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | FGFR1 K656N lies within the protein kinase domain of the Fgfr1 protein (UniProt.org). K656N has been associated with resistance to FGFR inhibitors in culture (PMID: 34114373), and results in increased kinase activity of a truncated Fgfr1 construct in an in vitro assay (PMID: 26864631), but has not been fully biochemically characterized and therefore, its effect on Fgfr1 protein function is unknown. |
Associated Drug Resistance | Y |
Category Variants Paths |
FGFR1 mutant FGFR1 K656N |
Transcript | NM_023110.3 |
gDNA | chr8:g.38414788C>G |
cDNA | c.1968G>C |
Protein | p.K656N |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |