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Gene TET2
Variant R1262A
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions TET2 R1262A lies within the catalytic domain of the Tet2 protein (PMID: 24315485). R1262A is predicted to confer a loss of function to the Tet2 protein as demonstrated by decreased enzymatic activity in cultured cells (PMID: 24315485).
Associated Drug Resistance
Category Variants Paths

TET2 mutant TET2 inact mut TET2 R1262A

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Transcript NM_001127208.3
gDNA chr4:g.105243759_105243760delCGinsGC
cDNA c.3784_3785delCGinsGC
Protein p.R1262A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005263082 chr4:g.105243759_105243760delCGinsGC c.3784_3785delCGinsGC p.R1262A RefSeq GRCh38/hg38
XM_005263082.4 chr4:g.105243759_105243760delCGinsGC c.3784_3785delCGinsGC p.R1262A RefSeq GRCh38/hg38
XM_024454103.1 chr4:g.105243759_105243760delCGinsGC c.3784_3785delCGinsGC p.R1262A RefSeq GRCh38/hg38
XM_024454103.2 chr4:g.105243759_105243760delCGinsGC c.3784_3785delCGinsGC p.R1262A RefSeq GRCh38/hg38
NM_001127208.3 chr4:g.105243759_105243760delCGinsGC c.3784_3785delCGinsGC p.R1262A RefSeq GRCh38/hg38
NM_001127208.2 chr4:g.105243759_105243760delCGinsGC c.3784_3785delCGinsGC p.R1262A RefSeq GRCh38/hg38
NM_001127208 chr4:g.105243759_105243760delCGinsGC c.3784_3785delCGinsGC p.R1262A RefSeq GRCh38/hg38
XM_005263082.3 chr4:g.105243759_105243760delCGinsGC c.3784_3785delCGinsGC p.R1262A RefSeq GRCh38/hg38
XM_024454102.1 chr4:g.105243759_105243760delCGinsGC c.3784_3785delCGinsGC p.R1262A RefSeq GRCh38/hg38
XM_024454102.2 chr4:g.105243759_105243760delCGinsGC c.3784_3785delCGinsGC p.R1262A RefSeq GRCh38/hg38

Filtering

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Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References