FGFR1 P150S
Gene Variant Detail

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Gene FGFR1
Variant P150S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR1 P150S lies within the extracellular domain of the Fgfr1 protein (UniProt.org). P150S results in altered proliferation relative to wild-type Fgfr1 in a competition assay, but results in transformation activity similar to wild-type Fgfr1 in cultured cells (PMID: 34272467), and therefore, its effect on Fgfr1 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 P150S

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Transcript NM_023110.3
gDNA chr8:g.38428346G>A
cDNA c.448C>T
Protein p.P150S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001174063.2 chr8:g.38428346G>A c.448C>T p.P150S RefSeq GRCh38/hg38
NM_023110.2 chr8:g.38428346G>A c.448C>T p.P150S RefSeq GRCh38/hg38
XM_017013221.2 chr8:g.38428346G>A c.448C>T p.P150S RefSeq GRCh38/hg38
XM_017013229 chr8:g.38418238G>A c.448C>T p.P150S RefSeq GRCh38/hg38
XM_017013229.2 chr8:g.38418238G>A c.448C>T p.P150S RefSeq GRCh38/hg38
XM_017013230 chr8:g.38418238G>A c.448C>T p.P150S RefSeq GRCh38/hg38
XM_006716303.3 chr8:g.38428346G>A c.448C>T p.P150S RefSeq GRCh38/hg38
XM_017013222.2 chr8:g.38428346G>A c.448C>T p.P150S RefSeq GRCh38/hg38
NM_023110.3 chr8:g.38428346G>A c.448C>T p.P150S RefSeq GRCh38/hg38
XM_017013221 chr8:g.38428346G>A c.448C>T p.P150S RefSeq GRCh38/hg38
NM_001174064.1 chr8:g.38428070G>A c.448C>T p.P150S RefSeq GRCh38/hg38
XM_006716309 chr8:g.38428070G>A c.448C>T p.P150S RefSeq GRCh38/hg38
XM_024447097.1 chr8:g.38428070G>A c.448C>T p.P150S RefSeq GRCh38/hg38
XM_017013222 chr8:g.38428346G>A c.448C>T p.P150S RefSeq GRCh38/hg38
XM_017013230.1 chr8:g.38418238G>A c.448C>T p.P150S RefSeq GRCh38/hg38
XM_006716304.1 chr8:g.38428346G>A c.448C>T p.P150S RefSeq GRCh38/hg38
XM_006716303 chr8:g.38428346G>A c.448C>T p.P150S RefSeq GRCh38/hg38
XM_006716303.4 chr8:g.38428346G>A c.448C>T p.P150S RefSeq GRCh38/hg38
XM_024447097.1 chr8:g.38428070G>A c.448C>T p.P150S RefSeq GRCh38/hg38
NM_001174063 chr8:g.38428346G>A c.448C>T p.P150S RefSeq GRCh38/hg38
NM_023110 chr8:g.38428346G>A c.448C>T p.P150S RefSeq GRCh38/hg38
NM_001174064 chr8:g.38428070G>A c.448C>T p.P150S RefSeq GRCh38/hg38
XM_006716304.2 chr8:g.38428346G>A c.448C>T p.P150S RefSeq GRCh38/hg38
XM_006716304 chr8:g.38428346G>A c.448C>T p.P150S RefSeq GRCh38/hg38
NM_001174063.1 chr8:g.38428346G>A c.448C>T p.P150S RefSeq GRCh38/hg38
XM_047421570.1 chr8:g.38428346G>A c.448C>T p.P150S RefSeq GRCh38/hg38
XM_017013221.1 chr8:g.38428346G>A c.448C>T p.P150S RefSeq GRCh38/hg38
NM_001174064.2 chr8:g.38428070G>A c.448C>T p.P150S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR1 P150S Advanced Solid Tumor predicted - sensitive Pemigatinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 P150S were sensitive to treatment with Pemazyre (pemigatinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR1 P150S Advanced Solid Tumor predicted - sensitive E7090 Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 P150S were sensitive to treatment with E7090 in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR1 P150S Advanced Solid Tumor predicted - sensitive Infigratinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 P150S were sensitive to treatment with Truseltiq (infigratinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR1 P150S Advanced Solid Tumor predicted - sensitive Fexagratinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 P150S were sensitive to treatment with Fexagratinib (AZD4547) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467