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Gene FGFR1
Variant R576W
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR1 R576W lies within the protein kinase domain of the Fgfr1 protein (UniProt.org). R576W has been identified in sequencing studies (PMID: 16186508, PMID: 27149842), but has not been biochemically characterized and therefore, its effect on Fgfr1 protein function is unknown (PubMed, Oct 2024).
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 R576W

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Transcript NM_023110.3
gDNA chr8:g.38415998G>A
cDNA c.1726C>T
Protein p.R576W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006716304.2 chr8:g.38415998G>A c.1726C>T p.R576W RefSeq GRCh38/hg38
XM_006716304 chr8:g.38415998G>A c.1726C>T p.R576W RefSeq GRCh38/hg38
XM_006716303.3 chr8:g.38415998G>A c.1726C>T p.R576W RefSeq GRCh38/hg38
NM_023110.2 chr8:g.38415998G>A c.1726C>T p.R576W RefSeq GRCh38/hg38
XM_006716303 chr8:g.38415998G>A c.1726C>T p.R576W RefSeq GRCh38/hg38
XM_017013221 chr8:g.38415998G>A c.1726C>T p.R576W RefSeq GRCh38/hg38
NM_023110.3 chr8:g.38415998G>A c.1726C>T p.R576W RefSeq GRCh38/hg38
XM_017013221.2 chr8:g.38415998G>A c.1726C>T p.R576W RefSeq GRCh38/hg38
XM_017013221.1 chr8:g.38415998G>A c.1726C>T p.R576W RefSeq GRCh38/hg38
XM_006716304.1 chr8:g.38415998G>A c.1726C>T p.R576W RefSeq GRCh38/hg38
XM_006716303.4 chr8:g.38415998G>A c.1726C>T p.R576W RefSeq GRCh38/hg38
NM_023110 chr8:g.38415998G>A c.1726C>T p.R576W RefSeq GRCh38/hg38

Filtering

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References