FGFR2 C342R
Gene Variant Detail

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Gene FGFR2
Variant C342R
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions FGFR2 C342R lies within Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). C342R results in constitutive activation of the Fgfr2 dimer state in an in vitro assay (PMID: 27596331), and therefore, is predicted to lead to a gain of Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 C342R

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Transcript NM_000141.5
gDNA chr10:g.121517379A>G
cDNA c.1024T>C
Protein p.C342R
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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