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Gene FGFR2
Variant C342R
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions FGFR2 C342R lies within Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). C342R results in constitutive activation of the Fgfr2 dimer state in an in vitro assay (PMID: 27596331), and therefore, is predicted to lead to a gain of Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 C342R

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Transcript NM_000141.5
gDNA chr10:g.121517379A>G
cDNA c.1024T>C
Protein p.C342R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001320658 chr10:g.121517379A>G c.1024T>C p.C342R RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121517379A>G c.1024T>C p.C342R RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121517379A>G c.1024T>C p.C342R RefSeq GRCh38/hg38
NM_000141 chr10:g.121517379A>G c.1024T>C p.C342R RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121517379A>G c.1024T>C p.C342R RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121517379A>G c.1024T>C p.C342R RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References