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Gene TET2
Variant W1291R
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions TET2 W1291R lies within the DNA-interacting region of the Tet2 protein (UniProt.org). W1291R results in a loss of Tet2 enzymatic activity in a cell free assay (PMID: 24315485) and the conserved position in mouse Tet2 is unable to convert 5mC to 5hmC (PMID: 21057493).
Associated Drug Resistance
Category Variants Paths

TET2 mutant TET2 inact mut TET2 W1291R

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Transcript NM_001127208.3
gDNA chr4:g.105259686T>A
cDNA c.3871T>A
Protein p.W1291R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001127208 chr4:g.105259686T>A c.3871T>A p.W1291R RefSeq GRCh38/hg38
XM_005263082.3 chr4:g.105259686T>A c.3871T>A p.W1291R RefSeq GRCh38/hg38
XM_024454102.2 chr4:g.105259686T>A c.3871T>A p.W1291R RefSeq GRCh38/hg38
NM_001127208.3 chr4:g.105259686T>A c.3871T>A p.W1291R RefSeq GRCh38/hg38
NM_001127208.2 chr4:g.105259686T>A c.3871T>A p.W1291R RefSeq GRCh38/hg38
XM_024454103.1 chr4:g.105259686T>A c.3871T>A p.W1291R RefSeq GRCh38/hg38
XM_024454103.2 chr4:g.105259686T>A c.3871T>A p.W1291R RefSeq GRCh38/hg38
XM_005263082.4 chr4:g.105259686T>A c.3871T>A p.W1291R RefSeq GRCh38/hg38
XM_005263082 chr4:g.105259686T>A c.3871T>A p.W1291R RefSeq GRCh38/hg38
XM_024454102.1 chr4:g.105259686T>A c.3871T>A p.W1291R RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries