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Gene FGFR2
Variant E116K
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 E116K lies within Ig-like C2-type domain 1 of the Fgfr2 protein (UniProt.org). E116K has been identified in sequencing studies (PMID: 25035393), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 E116K

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Transcript NM_000141.5
gDNA chr10:g.121565468C>T
cDNA c.346G>A
Protein p.E116K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_022970.3 chr10:g.121565468C>T c.346G>A p.E116K RefSeq GRCh38/hg38
NM_001144917.1 chr10:g.121565468C>T c.346G>A p.E116K RefSeq GRCh38/hg38
NM_001320658 chr10:g.121565468C>T c.346G>A p.E116K RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121565468C>T c.346G>A p.E116K RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121565468C>T c.346G>A p.E116K RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121565468C>T c.346G>A p.E116K RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121565468C>T c.346G>A p.E116K RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121565468C>T c.346G>A p.E116K RefSeq GRCh38/hg38
NM_001144914 chr10:g.121565468C>T c.346G>A p.E116K RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121565468C>T c.346G>A p.E116K RefSeq GRCh38/hg38
NM_022970 chr10:g.121565468C>T c.346G>A p.E116K RefSeq GRCh38/hg38
NM_001144913 chr10:g.121565468C>T c.346G>A p.E116K RefSeq GRCh38/hg38
NM_001144917 chr10:g.121565468C>T c.346G>A p.E116K RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121565468C>T c.346G>A p.E116K RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121565468C>T c.346G>A p.E116K RefSeq GRCh38/hg38
NM_001144914.1 chr10:g.121565468C>T c.346G>A p.E116K RefSeq GRCh38/hg38
NM_000141 chr10:g.121565468C>T c.346G>A p.E116K RefSeq GRCh38/hg38
NM_001144914.1 chr10:g.121565468C>T c.346G>A p.E116K RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References