FGFR2 G338R
Gene Variant Detail

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Gene FGFR2
Variant G338R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 G338R lies within Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). G338R has been identified in sequencing studies (PMID: 38983151), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2025).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 G338R

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Transcript NM_000141.5
gDNA chr10:g.121517391C>T
cDNA c.1012G>A
Protein p.G338R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001320658.1 chr10:g.121517391C>T c.1012G>A p.G338R RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121517391C>T c.1012G>A p.G338R RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121517391C>T c.1012G>A p.G338R RefSeq GRCh38/hg38
NM_001320658 chr10:g.121517391C>T c.1012G>A p.G338R RefSeq GRCh38/hg38
NM_000141 chr10:g.121517391C>T c.1012G>A p.G338R RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121517391C>T c.1012G>A p.G338R RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 G338R Advanced Solid Tumor sensitive Erdafitinib Preclinical - Cell culture Actionable In a preclinical study, Balversa (erdafitinib) inhibited viability of cells expressing FGFR2 G338R in culture (PMID: 40526877). 40526877
FGFR2 G338R Advanced Solid Tumor sensitive Futibatinib Preclinical - Cell culture Actionable In a preclinical study, Lytgobi (futibatinib) inhibited viability of cells expressing FGFR2 G338R in culture (PMID: 40526877). 40526877
FGFR2 G338R Advanced Solid Tumor sensitive Pemigatinib Preclinical - Cell culture Actionable In a preclinical study, Pemazyre (pemigatinib) inhibited viability of cells expressing FGFR2 G338R in culture (PMID: 40526877). 40526877
FGFR2 G338R Advanced Solid Tumor sensitive Fexagratinib Preclinical - Cell culture Actionable In a preclinical study, Fexagratinib (AZD4547) inhibited viability of cells expressing FGFR2 G338R in culture (PMID: 40526877). 40526877