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Gene FGFR2
Variant G462E
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 G462E lies within the cytoplasmic domain of the Fgfr2 protein (UniProt.org). G462E has been identified in sequencing studies (PMID: 25035393), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 G462E

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Transcript NM_000141.5
gDNA chr10:g.121503844C>T
cDNA c.1385G>A
Protein p.G462E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001320654 chr10:g.121485521C>T c.1385G>A p.G462E RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121503844C>T c.1385G>A p.G462E RefSeq GRCh38/hg38
XM_017015924.3 chr10:g.121496722C>T c.1385G>A p.G462E RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121503844C>T c.1385G>A p.G462E RefSeq GRCh38/hg38
NM_001320654.1 chr10:g.121485521C>T c.1385G>A p.G462E RefSeq GRCh38/hg38
XM_017015924.2 chr10:g.121496722C>T c.1385G>A p.G462E RefSeq GRCh38/hg38
XM_017015924 chr10:g.121496722C>T c.1385G>A p.G462E RefSeq GRCh38/hg38
NM_000141 chr10:g.121503844C>T c.1385G>A p.G462E RefSeq GRCh38/hg38
NM_001320654.2 chr10:g.121485521C>T c.1385G>A p.G462E RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References