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Gene FGFR2
Variant G583V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 G583V lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). G583V has been identified in sequencing studies (PMID: 22980975, PMID: 26960398), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 G583V

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Transcript NM_000141.5
gDNA chr10:g.121496647C>A
cDNA c.1748G>T
Protein p.G583V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001144918 chr10:g.121485491C>A c.1748G>T p.G583V RefSeq GRCh38/hg38
NM_001144918.2 chr10:g.121485491C>A c.1748G>T p.G583V RefSeq GRCh38/hg38
NM_001144918.1 chr10:g.121485491C>A c.1748G>T p.G583V RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121496647C>A c.1748G>T p.G583V RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121496647C>A c.1748G>T p.G583V RefSeq GRCh38/hg38
NM_000141 chr10:g.121496647C>A c.1748G>T p.G583V RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References