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Gene FGFR2
Variant I547D
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 I547D lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). I547D has been identified in sequencing studies (PMID: 22383975), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 I547D

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Transcript NM_000141.5
gDNA chr10:g.121498527_121498528delATinsGA
cDNA c.1639_1640delATinsGA
Protein p.I547D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000141.4 chr10:g.121498527_121498528delATinsGA c.1639_1640delATinsGA p.I547D RefSeq GRCh38/hg38
XM_024447891.1 chr10:g.121488051_121488053delATAinsGAC c.1639_1641delATAinsGAC p.I547D RefSeq GRCh38/hg38
NM_000141 chr10:g.121498527_121498528delATinsTC c.1639_1640delATinsGA p.I547D RefSeq GRCh38/hg38
XM_006717712 chr10:g.121488051_121488053delTATinsGTC c.1639_1641delATAinsGAC p.I547D RefSeq GRCh38/hg38
XM_024447891.2 chr10:g.121488051_121488053delATAinsGAC c.1639_1641delATAinsGAC p.I547D RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121498527_121498528delATinsGA c.1639_1640delATinsGA p.I547D RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References