FGFR2 K420I
Gene Variant Detail

Request Content

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene FGFR2
Variant K420I
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 K420I lies within the cytoplasmic domain of the Fgfr2 protein (UniProt.org). K420I has been identified in sequencing studies (PMID: 25035393), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2025).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 K420I

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_000141.5
gDNA chr10:g.121515145T>A
cDNA c.1259A>T
Protein p.K420I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000141.4 chr10:g.121515145T>A c.1259A>T p.K420I RefSeq GRCh38/hg38
NM_001144915 chr10:g.121500860_121500861delCTinsGA c.1259_1260delAGinsTC p.K420I RefSeq GRCh38/hg38
NM_023029.2 chr10:g.121500860_121500861delAGinsTC c.1259_1260delAGinsTC p.K420I RefSeq GRCh38/hg38
NM_001144915.1 chr10:g.121500860_121500861delAGinsTC c.1259_1260delAGinsTC p.K420I RefSeq GRCh38/hg38
NM_001144915.2 chr10:g.121500860_121500861delAGinsTC c.1259_1260delAGinsTC p.K420I RefSeq GRCh38/hg38
XM_017015921.3 chr10:g.121515201_121515202delAGinsTC c.1259_1260delAGinsTC p.K420I RefSeq GRCh38/hg38
NM_000141 chr10:g.121515145T>A c.1259A>T p.K420I RefSeq GRCh38/hg38
NM_001320658 chr10:g.121515145T>A c.1259A>T p.K420I RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121515145T>A c.1259A>T p.K420I RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121515145T>A c.1259A>T p.K420I RefSeq GRCh38/hg38
XM_017015921 chr10:g.121515201_121515202delCTinsGA c.1259_1260delAGinsTC p.K420I RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121515145T>A c.1259A>T p.K420I RefSeq GRCh38/hg38
NM_023029.2 chr10:g.121500860_121500861delAGinsTC c.1259_1260delAGinsTC p.K420I RefSeq GRCh38/hg38
NM_023029 chr10:g.121500860_121500861delCTinsGA c.1259_1260delAGinsTC p.K420I RefSeq GRCh38/hg38
XM_017015921.2 chr10:g.121515201_121515202delAGinsTC c.1259_1260delAGinsTC p.K420I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References