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Gene | FGFR2 |
Variant | K420I |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | FGFR2 K420I lies within the cytoplasmic domain of the Fgfr2 protein (UniProt.org). K420I has been identified in sequencing studies (PMID: 25035393), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2024). |
Associated Drug Resistance | |
Category Variants Paths |
FGFR2 mutant FGFR2 K420I |
Transcript | NM_000141.5 |
gDNA | chr10:g.121515145T>A |
cDNA | c.1259A>T |
Protein | p.K420I |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_001320658.2 | chr10:g.121515145T>A | c.1259A>T | p.K420I | RefSeq | GRCh38/hg38 |
XM_017015921 | chr10:g.121515201_121515202delCTinsGA | c.1259_1260delAGinsTC | p.K420I | RefSeq | GRCh38/hg38 |
NM_001144915.1 | chr10:g.121500860_121500861delAGinsTC | c.1259_1260delAGinsTC | p.K420I | RefSeq | GRCh38/hg38 |
NM_023029.2 | chr10:g.121500860_121500861delAGinsTC | c.1259_1260delAGinsTC | p.K420I | RefSeq | GRCh38/hg38 |
NM_001144915 | chr10:g.121500860_121500861delCTinsGA | c.1259_1260delAGinsTC | p.K420I | RefSeq | GRCh38/hg38 |
NM_023029 | chr10:g.121500860_121500861delCTinsGA | c.1259_1260delAGinsTC | p.K420I | RefSeq | GRCh38/hg38 |
XM_017015921.2 | chr10:g.121515201_121515202delAGinsTC | c.1259_1260delAGinsTC | p.K420I | RefSeq | GRCh38/hg38 |
NM_001320658.1 | chr10:g.121515145T>A | c.1259A>T | p.K420I | RefSeq | GRCh38/hg38 |
NM_000141.5 | chr10:g.121515145T>A | c.1259A>T | p.K420I | RefSeq | GRCh38/hg38 |
NM_001144915.2 | chr10:g.121500860_121500861delAGinsTC | c.1259_1260delAGinsTC | p.K420I | RefSeq | GRCh38/hg38 |
NM_000141 | chr10:g.121515145T>A | c.1259A>T | p.K420I | RefSeq | GRCh38/hg38 |
NM_023029.2 | chr10:g.121500860_121500861delAGinsTC | c.1259_1260delAGinsTC | p.K420I | RefSeq | GRCh38/hg38 |
XM_017015921.3 | chr10:g.121515201_121515202delAGinsTC | c.1259_1260delAGinsTC | p.K420I | RefSeq | GRCh38/hg38 |
NM_000141.4 | chr10:g.121515145T>A | c.1259A>T | p.K420I | RefSeq | GRCh38/hg38 |
NM_001320658 | chr10:g.121515145T>A | c.1259A>T | p.K420I | RefSeq | GRCh38/hg38 |
Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
FGFR2 K420I | unknown |