FGFR2 K659M - Gene Variant Detail

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Gene FGFR2
Variant K659M
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions FGFR2 K659M (also referred to as K660M from the FGFR2IIIb isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). K659M results in increased kinase activity compared to wild-type Fgfr2 in substrate phosphorylation assays (PMID: 28166054), and therefore, is predicted to lead to a gain of Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 K659M

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Transcript NM_000141.5
gDNA chr10:g.121488001T>A
cDNA c.1976A>T
Protein p.K659M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_022970.4 chr10:g.121488003_121488004delAAinsTG c.1976_1977delAAinsTG p.K659M RefSeq GRCh38/hg38
NM_001144913 chr10:g.121488003_121488004delTTinsCA c.1976_1977delAAinsTG p.K659M RefSeq GRCh38/hg38
XM_006717708.4 chr10:g.121488054_121488055delAAinsTG c.1976_1977delAAinsTG p.K659M RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121488003_121488004delAAinsTG c.1976_1977delAAinsTG p.K659M RefSeq GRCh38/hg38
XM_017015920 chr10:g.121488054_121488055delTTinsCA c.1976_1977delAAinsTG p.K659M RefSeq GRCh38/hg38
NM_022970 chr10:g.121488003_121488004delTTinsCA c.1976_1977delAAinsTG p.K659M RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121488001T>A c.1976A>T p.K659M RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121488003_121488004delAAinsTG c.1976_1977delAAinsTG p.K659M RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121488003_121488004delAAinsTG c.1976_1977delAAinsTG p.K659M RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121488001T>A c.1976A>T p.K659M RefSeq GRCh38/hg38
XM_017015920.2 chr10:g.121488054_121488055delAAinsTG c.1976_1977delAAinsTG p.K659M RefSeq GRCh38/hg38
XM_017015920.3 chr10:g.121488054_121488055delAAinsTG c.1976_1977delAAinsTG p.K659M RefSeq GRCh38/hg38
XM_006717708.3 chr10:g.121488054_121488055delAAinsTG c.1976_1977delAAinsTG p.K659M RefSeq GRCh38/hg38
NM_000141 chr10:g.121488001T>A c.1976A>T p.K659M RefSeq GRCh38/hg38
XM_006717708 chr10:g.121488054_121488055delTTinsCA c.1976_1977delAAinsTG p.K659M RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 K659M Advanced Solid Tumor predicted - sensitive Lirafugratinib Preclinical - Biochemical Actionable In a preclinical study, Lirafugratinib treatment inhibited Fgfr2 phosphorylation in cultured cells expressing FGFR2 K659M (PMID: 37270847). 37270847