FGFR2 L397M
Gene Variant Detail

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Gene FGFR2
Variant L397M
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 L397M lies within the transmembrane domain of the Fgfr2 protein (UniProt.org). L397M has been identified in sequencing studies (PMID: 22383975), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Dec 2025).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 L397M

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Transcript NM_000141.5
gDNA chr10:g.121515215G>T
cDNA c.1189C>A
Protein p.L397M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001320658.1 chr10:g.121515215G>T c.1189C>A p.L397M RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121515215G>T c.1189C>A p.L397M RefSeq GRCh38/hg38
NM_000141 chr10:g.121515215G>T c.1189C>A p.L397M RefSeq GRCh38/hg38
NM_001320658 chr10:g.121515215G>T c.1189C>A p.L397M RefSeq GRCh38/hg38
XM_024447888.2 chr10:g.121503825_121503827delCTTinsATG c.1189_1191delCTTinsATG p.L397M RefSeq GRCh38/hg38
XM_017015922 chr10:g.121503825_121503827delAAGinsCAT c.1189_1191delCTTinsATG p.L397M RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121515215G>T c.1189C>A p.L397M RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121515215G>T c.1189C>A p.L397M RefSeq GRCh38/hg38
XM_024447888.1 chr10:g.121503825_121503827delCTTinsATG c.1189_1191delCTTinsATG p.L397M RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References