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Gene FGFR2
Variant L551I
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 L551I lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). L551I has been identified in sequencing studies (PMID: 22810696, PMID: 38983151), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 L551I

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Transcript NM_000141.5
gDNA chr10:g.121498516G>T
cDNA c.1651C>A
Protein p.L551I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000141 chr10:g.121498516G>T c.1651C>A p.L551I RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121498519G>T c.1651C>A p.L551I RefSeq GRCh38/hg38
XM_017015924.3 chr10:g.121488038G>T c.1651C>A p.L551I RefSeq GRCh38/hg38
XM_017015924 chr10:g.121488038G>T c.1651C>A p.L551I RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121498519G>T c.1651C>A p.L551I RefSeq GRCh38/hg38
NM_022970 chr10:g.121498519G>T c.1651C>A p.L551I RefSeq GRCh38/hg38
XM_006717710.4 chr10:g.121498574_121498576delCTGinsATC c.1651_1653delCTGinsATC p.L551I RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121498519G>T c.1651C>A p.L551I RefSeq GRCh38/hg38
XM_006717710 chr10:g.121498574_121498576delCAGinsGAT c.1651_1653delCTGinsATC p.L551I RefSeq GRCh38/hg38
XM_006717710.5 chr10:g.121498574_121498576delCTGinsATC c.1651_1653delCTGinsATC p.L551I RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121498519G>T c.1651C>A p.L551I RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121498516G>T c.1651C>A p.L551I RefSeq GRCh38/hg38
NM_001144913 chr10:g.121498519G>T c.1651C>A p.L551I RefSeq GRCh38/hg38
XM_017015924.2 chr10:g.121488038G>T c.1651C>A p.L551I RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121498516G>T c.1651C>A p.L551I RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References