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Gene FGFR2
Variant M186T
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions FGFR2 M186T lies within Ig-like C2-type domain 2 of the Fgfr2 protein (UniProt.org). M186T is a common Fgfr2 polymorphism (PMID: 11781872, PMID: 25129254) that results in similar cell proliferation and viability levels as wild-type Fgfr2 (PMID: 29533785), and proliferation similar to wild-type in a competition assay, but decreased transformation activity in cultured cells (PMID: 34272467), and therefore, is predicted to lead to a loss of Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 exon5 FGFR2 M186T

FGFR2 mutant FGFR2 inact mut FGFR2 M186T

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Transcript NM_000141.5
gDNA chr10:g.121551357A>G
cDNA c.557T>C
Protein p.M186T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001144917 chr10:g.121551357A>G c.557T>C p.M186T RefSeq GRCh38/hg38
NM_001144914 chr10:g.121551357A>G c.557T>C p.M186T RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121551357A>G c.557T>C p.M186T RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121551357A>G c.557T>C p.M186T RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121551357A>G c.557T>C p.M186T RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121551357A>G c.557T>C p.M186T RefSeq GRCh38/hg38
NM_001144914.1 chr10:g.121551357A>G c.557T>C p.M186T RefSeq GRCh38/hg38
NM_001320658 chr10:g.121551357A>G c.557T>C p.M186T RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121551357A>G c.557T>C p.M186T RefSeq GRCh38/hg38
NM_001144917.1 chr10:g.121551357A>G c.557T>C p.M186T RefSeq GRCh38/hg38
NM_000141 chr10:g.121551357A>G c.557T>C p.M186T RefSeq GRCh38/hg38
NM_001144913 chr10:g.121551357A>G c.557T>C p.M186T RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121551357A>G c.557T>C p.M186T RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121551357A>G c.557T>C p.M186T RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121551357A>G c.557T>C p.M186T RefSeq GRCh38/hg38
NM_001144914.1 chr10:g.121551357A>G c.557T>C p.M186T RefSeq GRCh38/hg38
NM_022970 chr10:g.121551357A>G c.557T>C p.M186T RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121551357A>G c.557T>C p.M186T RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 M186T Advanced Solid Tumor predicted - sensitive Fexagratinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 M186T were sensitive to treatment with AZD4547 in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 M186T Advanced Solid Tumor predicted - sensitive Infigratinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 M186T were sensitive to treatment with Truseltiq (infigratinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 M186T Advanced Solid Tumor predicted - resistant Dovitinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 M186T were resistant to treatment with Dovitinib (TKI258) in culture (PMID: 34272467). 34272467
FGFR2 M186T Advanced Solid Tumor predicted - sensitive Erdafitinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 M186T were sensitive to treatment with Balversa (erdafitinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 M186T Advanced Solid Tumor predicted - sensitive Futibatinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 M186T were sensitive to treatment with Lytgobi (futibatinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 M186T Advanced Solid Tumor predicted - sensitive Pemigatinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 M186T were sensitive to treatment with Pemazyre (pemigatinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 M186T Advanced Solid Tumor predicted - sensitive E7090 Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 M186T were sensitive to treatment with E7090 in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467