FGFR2 M391R - Gene Variant Detail

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Gene FGFR2
Variant M391R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 M391R lies within the transmembrane domain of the Fgfr2 protein (UniProt.org). The functional effect of M391R is conflicting, as it has been reported to result in increased nucleolar Fgfr2 activity and cell proliferation in one study (PMID: 24908667), but results in similar cell proliferation and viability levels to wild-type Fgfr2 in two different cell lines in another study (PMID: 29533785), and therefore, its effect on Fgfr2 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 M391R

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Transcript NM_000141.5
gDNA chr10:g.121515232A>C
cDNA c.1172T>G
Protein p.M391R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000141.4 chr10:g.121515232A>C c.1172T>G p.M391R RefSeq GRCh38/hg38
NM_000141 chr10:g.121515232A>C c.1172T>G p.M391R RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121515232A>C c.1172T>G p.M391R RefSeq GRCh38/hg38
NM_001320658 chr10:g.121515232A>C c.1172T>G p.M391R RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121515232A>C c.1172T>G p.M391R RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121515232A>C c.1172T>G p.M391R RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References