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Gene FGFR2
Variant M537I
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions FGFR2 M537I (also referred to as M538I from the FGFR2IIIb isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). M537I results in elevated kinase activity compared to wild-type Fgfr2 protein in substrate phosphorylation assays (PMID: 28166054), and therefore, is predicted to lead to a gain of Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 M537I

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Transcript NM_000141.5
gDNA chr10:g.121498556C>G
cDNA c.1611G>C
Protein p.M537I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000141 chr10:g.121498556C>G c.1611G>C p.M537I RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121498556C>G c.1611G>C p.M537I RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121498556C>G c.1611G>C p.M537I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
FGFR2 M537I gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 M537I FGFR2 V564L FGFR2 amp