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Gene FGFR2
Variant M584V
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions FGFR2 M584V lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). M584V results in decreased Erk phosphorylation in cell culture (PMID: 38561822), and therefore is predicted to lead to a loss of Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 inact mut FGFR2 M584V

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Transcript NM_000141.5
gDNA chr10:g.121496645T>C
cDNA c.1750A>G
Protein p.M584V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000141 chr10:g.121496645T>C c.1750A>G p.M584V RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121496645T>C c.1750A>G p.M584V RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121496645T>C c.1750A>G p.M584V RefSeq GRCh38/hg38

Filtering

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References