Gene Variant Detail

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Gene FGFR2
Variant P582L
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR2 P582L lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). P582L results in proliferation similar to wild-type Fgfr2 in a competition assay and transformation activity similar to wild-type in cultured cells (PMID: 34272467), and therefore, is predicted to have no effect on Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 P582L

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Transcript NM_000141.5
gDNA chr10:g.121496650G>A
cDNA c.1745C>T
Protein p.P582L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001320654 chr10:g.121479894G>A c.1745C>T p.P582L RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121496650G>A c.1745C>T p.P582L RefSeq GRCh38/hg38
NM_001144913 chr10:g.121496653G>A c.1745C>T p.P582L RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121496653G>A c.1745C>T p.P582L RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121496653G>A c.1745C>T p.P582L RefSeq GRCh38/hg38
NM_001320654.2 chr10:g.121479894G>A c.1745C>T p.P582L RefSeq GRCh38/hg38
NM_022970 chr10:g.121496653G>A c.1745C>T p.P582L RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121496650G>A c.1745C>T p.P582L RefSeq GRCh38/hg38
NM_000141 chr10:g.121496650G>A c.1745C>T p.P582L RefSeq GRCh38/hg38
NM_001320654.1 chr10:g.121479894G>A c.1745C>T p.P582L RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121496653G>A c.1745C>T p.P582L RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121496653G>A c.1745C>T p.P582L RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 P582L Advanced Solid Tumor predicted - sensitive Fexagratinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 P582L were sensitive to treatment with AZD4547 in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 P582L Advanced Solid Tumor predicted - sensitive Infigratinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 P582L were sensitive to treatment with Truseltiq (infigratinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 P582L Advanced Solid Tumor predicted - sensitive E7090 Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 P582L were sensitive to treatment with E7090 in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 P582L Advanced Solid Tumor predicted - sensitive Erdafitinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 P582L were sensitive to treatment with Balversa (erdafitinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 P582L Advanced Solid Tumor predicted - sensitive Futibatinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 P582L were sensitive to treatment with Lytgobi (futibatinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 P582L Advanced Solid Tumor predicted - sensitive Pemigatinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 P582L were sensitive to treatment with Pemazyre (pemigatinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467