Gene Variant Detail

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Gene FGFR2
Variant P582L
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR2 P582L lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). P582L results in proliferation similar to wild-type Fgfr2 in a competition assay and transformation activity similar to wild-type in cultured cells (PMID: 34272467), and therefore, is predicted to have no effect on Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 P582L

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Transcript NM_000141.5
gDNA chr10:g.121496650G>A
cDNA c.1745C>T
Protein p.P582L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001320654 chr10:g.121479894G>A c.1745C>T p.P582L RefSeq GRCh38/hg38
NM_001320654.2 chr10:g.121479894G>A c.1745C>T p.P582L RefSeq GRCh38/hg38
NM_001144913 chr10:g.121496653G>A c.1745C>T p.P582L RefSeq GRCh38/hg38
NM_022970 chr10:g.121496653G>A c.1745C>T p.P582L RefSeq GRCh38/hg38
NM_001320654.1 chr10:g.121479894G>A c.1745C>T p.P582L RefSeq GRCh38/hg38
NM_000141 chr10:g.121496650G>A c.1745C>T p.P582L RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121496653G>A c.1745C>T p.P582L RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121496650G>A c.1745C>T p.P582L RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121496650G>A c.1745C>T p.P582L RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121496653G>A c.1745C>T p.P582L RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121496653G>A c.1745C>T p.P582L RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121496653G>A c.1745C>T p.P582L RefSeq GRCh38/hg38

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries